The pH values of all developed formulations (F1 to F9) and marketed gel formulation ranged from 5.94±0.18 to 6.94±0.27, which are considered acceptable . Finally, the skin irritation test was carried out only on selected formulations…
Structure and function of the skin. Solvents like glycerin and propylene glycol can alter rheology and drug delivery characteristics of topical gels owing to their different viscosities and due to the change in solvent-polymer and solvent-solvent interactions. Tis- ... topical l-ascorbic acid 139 ... formulate for topical use, more stable derivatives of L-ascorbic acid have been utilized in topical formula-tions. Pharm., Ph. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. used in topical gel formulations. Topical preparations 1. to carbopol solution and the pH was then adjusted to 7.4 by stirring the solution for 10 min. 3.1.2.
Spreadability.
It is extracted from the essential oil of various medicinal plants. pH Fifteen percent formulations of L-ascorbic acid were tested at pH levels between 2.0 and 5.0 (Figure 1). Methods.
alcohol and chlorhexidine and with the most commonly used compounds in topical formulations. Spreadability of semisolid formulations, that is, the ability of a cream or gel to evenly spread on the skin, plays an important role in the administration of a standard dose of a medicated formulation to the skin and the efficacy of a topical therapy. E-mail: nanjwadebk@gmail.com 2014/05/25 1 Faculty of Pharmacy, Omer Al-Mukhtar University, Tobruk, Libya 2. For formulation design, simplicity is the basis of good formulation design and the shorter the ingredient list, the better. Although esters of ascorbic acid are more stable Rheological properties and antibacterial activity were also evaluated. CONTENTS 1. 2.
To conclude, the right formulation for topical drug development is determined by the properties of the drug substance, excipients, and the intended target area. Then propylene glycol solution was added with stirring for 10 min until a clear consistent gel base was obtained. Preparation of gel formulation Twelve topical gel formulation was prepared using CHME (methanol leaf extract of Cardiospermum FORMULATION OF OINTMENT: FORMULATION OF OINTMENT 1) Drug 2) Base 3) Preservative 4) Anti-oxidant 5) Chelating agents 6) Perfumes 1) Drug:- Active Pharmaceutical Ingredient produced desired therapeutic action 2) Base:- Serve as a vehicle for the medicament Aqueous gels with different pH … Good formulators eliminate redundant elements and integrate components when possible . Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. carboxylic acid groups of carbopol 940 to pH 6.8 ± 0.2 [8].
All the more, the pH of the formulations, particularly how they react to the pH factors in different layers of the skin, is very important. Topical preparation Dr. Basavaraj K. NanjwadeM. Mixing Quats with ordinary soaps and/or with anionic detergents may decrease the activity. Formulation components for topical drug products are briefly summarized in Table II. Evaluation of the gels The gels containing essential oil were examined for their physical properties. Topical Gel: A Recent Approach for Novel Drug delivery Loveleen Preet Kaur*, Tarun Kumar Guleri Department of Pharmaceutics, Sri Sai College of Pharmacy, Pathankot, Punjab State, India. D Department of Pharmaceutics Faculty of Pharmacy Omer Al-Mukhtar University Tobruk, Libya. ABSTRACT Gel formulation provides better application property and stability in comparison to cream and ointment. Compatibility: Quats can be combined with e.g.
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